Brief address

The US is a powerful country that does not need to prove itself by beating up smaller countries.

There was no casus belli in Iraq.

Occupation will not pacify Iraq, nor should we have any right to expect a reward for our illegal invasion.

As a brave American once said, “You know, this war is so fucking illegal.”

Free the press

Thanks to whoever it was that sent this article to me.

Dosing Medical Marijuana: Rational Guidelines on Trial in Washington State
Posted 09/11/2007

Sunil K. Aggarwal, MS III, PhC, BS, BA; Muraco Kyashna-Tocha, PhD; Gregory T. Carter, MD, MS

Introduction
The medicinal value of cannabis is well documented in the medical literature.[1,2] Cannabinoids, the active ingredients, are found in the resin-producing pistillate inflorescences of the Cannabis sativa plant.[3] Since the early 1900s, cannabis has been referred to as mari(h/j)uana, a pejorative term derived from Mexican Spanish-Portuguese colloquial slang. Cannabinoids have many distinct pharmacologic properties. These include analgesic, antiemetic, antioxidative, neuroprotective, and anti-inflammatory activity, as well as modulation of glial cells and tumor growth regulation.[1] We now know that there is an endogenous molecular signaling system in our bodies that is run by cannabinoids. The discovery of this endogenous cannabinoid system with specific receptors and ligands has led to the progression of our understanding of the therapeutic actions of cannabis from folklore to valid science.[4] It now appears that the cannabinoid system evolved with our species and is intricately involved in normal human physiology, specifically in the control of movement, pain, appetite, memory, immunity, and inflammation, among others. The detection of widespread cannabinoid receptors in the brain and peripheral tissues suggests that the cannabinoid system represents a previously unrecognized, ubiquitous network in the nervous system. On that basis, exogenous cannabinoids appear to have tremendous potential in treating neurodegenerative disorders.[5,6] For example, in amyotrophic lateral sclerosis (ALS), there is animal model evidence that exogenous cannabinoids have disease-modifying potential.[7-12] Further, in a large survey, ALS patients reported that marijuana relieved the major symptoms of the disease better than prescription medications.[13] The most common reason cited by ALS patients for not considering using cannabis to treat their symptoms was lack of access.[13]

Dense cannabinoid receptor concentrations have been found in the cerebellum, basal ganglia, and hippocampus, accounting for the effects of cannabis on motor tone, coordination, and mood state.[4] Low concentrations are found in the brainstem, accounting for the remarkably low toxicity of cannabis. Of note, lethal doses for cannabis in humans have not been described. So far, we know of at least 2 molecular receptor proteins (CB1 and CB2) and 2 endogenously produced lipid cannabinoids (anandamide and 2-acylglycerol) found in numerous tissues throughout the body, including neural and immune tissues, which comprise the endogenous cannabinoid system.[1,3,4] The cannabinoid system helps regulate the function of other systems in the body, making it an integral part of the central homeostatic modulatory system — the check-and-balance molecular signaling network in our bodies that keeps us at a healthy “98.6.” Despite all of the advances in understanding the physiology and pharmacology of cannabis and cannabinoids, there remains a strong need for developing rational guidelines for dosing cannabis. We (Gregory T. Carter [GTC] and Muraco Kyashna-Tocha [MKT]) have previously attempted to address this issue, deriving a dosing scheme with the available known chemistry and pharmacology of cannabis.[14] However, it would appear that there is still considerable controversy over this issue. Read the rest of this entry »

I wouldn’t inflict them on the Iraqis, though. The Hague is very nice this time of year, isn’t it?

Guess he’s your party man?

David Kurtz has this to say:

Conservative super-lawyer Ted Olson is the front-runner to be President Bush’s pick for attorney general. Senate Dems are less than thrilled, but if last week’s 4th Circuit nominee is any indication (oh, and the last 6 1/2 years), the White House will not be offering a consensus-building nominee. We already know that Senate Democrats are threatening to slow down the nomination until they get responses from the Department of Justice and White House to some of their oversight requests, but will Senate Dems fight this nomination on its merits?

Wikipedia has this to say:

Olson’s third wife, Barbara K. Olson, was a passenger on the hijacked American Airlines Flight 77 that was crashed into the Pentagon on September 11, 2001 (his 61st birthday). The following year Olson met Lady Booth, a tax attorney and native of Kentucky, and the two were married on October 21, 2006 in Napa County, California [4]. Booth has described herself as a Democrat; her only federal campaign contribution has been to $2,300 to Republican presidential candidate Rudy Giuliani [2]. Olson also has contributed nearly $3000 in his own name to Giuliani, as well as to other Republican politicians and PACs. [3]

Fasten your seatbelts